Knowledge in the era of knowledge economy means not only professional, education, skills or patent development, but also innovative, dynamic changes for the development of new tools, new processes, new resources, new ideas and new actions. As technical developments affect individuals, households, and businesses more directly and more deeply, factors such as how to handle the falling of borders among organizations and nations, how to extend the confines of business cooperation, how to enter the areas of cross-field interaction and innovation, how to listen attentively to customers’ requirements, how to let customers be more involved in research and development (R&D), how to build multiple directions and prompt communication channels, how to integrate virtual and real resources, how to develo p the power of team intelligence, how to work together on project s, how to quickly create a web of public relationship s, and how to facilitate knowledge sharing, are all necessary for businesses to conquer the shrinking profit margin issue. We propose a conceptual framework for addressing the ten trends of knowledge economy development, including globalization, collaboration, intersectional innovation, customerization, diversified communication, virtualization, individualization, outsourcing, social-networking, and knowledge-sharing. Each trend is an additional turning point for a business. For example, globalization is a ways to deal with costly materials, collaboration can be helpful for business on too small a scale, intersectional innovation helps deal with the non-direction of a business organization, customerization helps deal with overstock problems, diversified communication can remedy time consuming work, virtualization can help deal with insufficient resources in an organization, individualization can help deal with the problem of an unknown brand, outsourcing can help deal with an insufficient labor force, social-networking can help deal with the lack of personal networks, knowledge-sharing can help deal with the lack of a knowledge base. If a business can design an ideal solution scheme for each turning point, it may overcome the current problem with shrinking profit margin, so as to promote the development of the business into a knowledge industry, and further help in the transformation, upgrading and growth of that business.